Methods of reducing blood loss and non-blood substitutes

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Blood and blood substitutes.

Each year, in Europe, approximately seven million units of colloidal plasma substitutes are given to patients. Often they are used uncritically, which may account for the increased incidence of sideeffects which has been noted over the last decade. Their increasing use is understandable in view of the disadvantages of using blood; these include the difficulties in finding sufficient donors of a...

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Blood substitutes

Blood substitutes have long been sought after, and artificial oxygen carriers may soon become a reality. Despite increased safety of allogeneic blood in terms of transmission of infectious diseases [1], avoiding allogeneic blood transfusions remains an important goal in perioperative and intensive care medicine. This is because allogeneic blood transfusions may cause immunosuppression with an i...

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Physiological properties of blood substitutes.

Blood substitutes (modified hemoglobin solutions, perfluorocarbon emulsions) serve as artificial oxygen carriers and are alternatives to blood transfusions. Hemoglobin solutions mimic the sigmoidal oxygen dissociation curve of natural blood. Perfluorocarbon emulsions exhibit a linear relation between PO2 and dissolved oxygen. The most advanced substances may enter medicine in few years.

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Comparing methods of tranexamic acid administration and blood reinfusion in reducing blood loss during total knee arthroplasty

Background: Perioperative blood loss is associated with total knee arthroplasty (TKA). The tranexamic acid (TXA) is a plasminogen activator inhibitor widely used to prevent bleeding. The Stryker CBC II ConstaVac Blood Conservation System (CBC II, Stryker) can avoid homologous blood. The purpose of this study is to compare the efficacy of intravenous and topical regimen of TXA in primary TKA, an...

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Trauma and military applications of blood substitutes.

PURPOSE To review potential clinical uses of erythrocyte substitutes in treating military battlefield casualties, with specific emphasis on combat injury rates and wounding patterns, resuscitation doctrine and logistic requirements. METHODS Review of published medical literature and of unclassified documents from the U.S. Armed Forces Blood Program. RESULTS Hemorrhage is the leading cause o...

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ژورنال

عنوان ژورنال: Canadian Journal of Anaesthesia

سال: 1991

ISSN: 0832-610X,1496-8975

DOI: 10.1007/bf03008191